Rockefeller University Research Assistant in New York, New York

Job Title Research Assistant

Laboratory / Department Human Genetics of Infectious Diseases

Department Description

The Laboratory of Human Genetics of Infectious Diseases studies the genetics of human predisposition to pediatric infectious diseases, particularly mycobacterial diseases, invasive pneumococcal diseases and herpes simplex encephalitis. It aims to identify Mendelian 'holes' in the immune defense of otherwise healthy children who are susceptible to specific infectious diseases, work that has profound implications for and has resulted in a paradigm shift in human clinical medicine and fundamental immunology. In the past decade, the laboratory has uncovered that single genetic lesions in children confer severe and selective vulnerability to certain illnesses, whereas corresponding infections in adults result more from polygenetic inheritance. This work not only blurs the distinction between patient-based Mendelian genetics and population-based complex genetics but has also provided experimental support for a unified theory of human infectious diseases.

Detailed Description

The Research Assistant will engage in experiments focused on the genetic dissection of human infectious diseases. Will perform basic and advanced laboratory experiments in molecular biology and immunology to generate and characterize mutations in a specific immune related gene. The Research Assistant will identify specific transcription factors and analyze the functional characterization of specific mutations in candidate genes.

Job Requirements

Bachelor's degree in science required; educational emphasis in biochemistry, molecular genetics, immunology, or related field preferred. Must have two years of molecular biology experience. Experience with tissue culture, DNA cloning, qPCR, Western Blotting, and flow cytometry preferred. Must be detail-oriented, have a strong sense of responsibility and be able to work as part of a team in a fast-paced environment. Good record keeping, strong interpersonal and communication skills, and computer proficiency required.

Additional Details

The Rockefeller University is an Equal Opportunity Employer - Minorities/Women/Disabled/Veterans