Rockefeller University Research Assistant in New York, New York
Job Title Research Assistant
Laboratory / Department Chemical Immunology and Proteomics
The Laboratory of Chemical Immunology and Proteomics applies synthetic chemistry, chemical biology, and proteomics methods toward the goals of discovering and characterizing (a) novel selective chemical probes that perturb the functions of key proteins regulating immunological and neuroimmunological processes; (b) new mechanisms for small molecule-induced protein degradation; and, more broadly, (c) the pharmacological landscape and signal transduction pathways in immune and neuroimmunological disorders. Achieving these objectives is enhanced through the development of new chemical scaffolds targeting cysteine and other nucleophilic residues. By developing and applying innovative chemical proteomic profiling technologies, we aim to enrich our understanding of the molecular differences between pathologic and physiologic states in immune cells and cells of the nervous system (including microglia and oligodendrocytes, which are implicated in the autoimmune disorder multiple sclerosis). The lab also plans to explore how those differences can be further leveraged from a pharmacological perspective for the development of new therapies that not only target specific immune cell subtypes, but also the defined activation states of these cells. Please see www.vinogradovalab.com for more information.
The Research Assistant will work with other lab members on a project involving development of new mouse models for chemical proteomic studies of neuroinflammation and functional validation of prioritized protein targets in primary immune cells and neuroglia. This research is highly collaborative and is expected to provide new insights into post-translational drivers of immune misregulation and opportunities for pharmacological modulation with small-molecule electrophiles. The Research Assistant will be responsible for maintenance of mouse colonies, mouse dissection for collection of tissue samples, mouse genotyping, tail vein injection, subcutaneous and intraperitoneal injections, analytical techniques such as real-time quantitative PCR, Western blot analysis, and immunohistochemistry, and extraction of nucleic acids and proteins from mouse and cell culture samples. Future responsibilities will also include molecular biological approaches, including cloning and experiments with DNA, RNA, and proteins to support the lab's science. During the full length of the appointment, you will also work with several lab members to support general Laboratory operations in the areas of purchasing and laboratory organization.
Bachelor's degree in science and previous biochemistry or cell biology experience is required. Mouse experience is a plus, but not a pre-requisite. Must be highly motivated and driven by scientific curiosity, possess excellent verbal, written, and electronic communication skills, and interact effectively in a collaborative work environment. Must have excellent organizational skills, including laboratory record keeping, data management, and prioritizing work to carry out complex experiments with extreme attention to detail. Previous independent research experience or extensive laboratory coursework is strongly preferred. Must be amenable to a changing work schedule that prioritizes experiments and often deviates from the standard 9 to 5 workday, occasionally including weekend hours.
This job requires that employees be fully vaccinated against COVID-19 as a condition of employment. Rockefeller University provides reasonable accommodations where legally required including accommodations for medical conditions and sincerely held religious beliefs.
The Rockefeller University is an Equal Opportunity Employer - Minorities/Women/Disabled/Veterans