Rockefeller University Research Support Specialist in New York, New York
Job Title Research Support Specialist
Laboratory / Department Cryo-Electron Microscopy Resource Center
The Evelyn Gruss Lipper Cryo-Electron Microscopy Resource Center (CEMRC) provides its users with a world class environment to make advances in structural biology. The center is equipped with three high end dedicated cryo-electron microscopes. The microscopy suite was meticulously and specially designed to allow these instruments to perform beyond their specified resolutions. This center provides users with the world's most stable dedicated cryo-electron microscopes optimized for high resolution single particle analysis of proteins and protein complexes as well as high resolution cellular tomography. Users work alongside CEMRC staff until they have mastered electron microscope operation at which point they work autonomously.
The Research Support Specialist will provide support for single particle and tomography analysis to users of the University's Cryo-EM Resource Center (CEMRC). Will work with and support existing CEMRC staff and researchers in detailed structural analysis of proteins and other biological macromolecules, as well as in daily technical and administrative functions, including sample prep, instrument operation, scheduling and tracking use, and supply management. Will work in collaboration with the University's Information Technology Department to develop and support the high throughput data collection, management, and analysis needs of the CEMRC. Responsibilities include training CERMC users on the use of image processing applications and analysis, providing consulting services to users on data analysis and interpretation of results, cataloging and disseminating information on available software, continuously evaluating updates to relevant software packages and implementing new tools, liaising with SBGrid and other relevant consortia, participating in professional development opportunities to keep up-to-date with current approaches and technologies, operating and maintaining CryoEM and related instrumentation, and provided administrative and logistical support of day-to-day operations, including session scheduling, usage tracking and reporting, and materials acquisition.
Bachelor's degree in science required; advanced degree and educational emphasis in structural biology, biophysics, bioinformatics, computer science, engineering or closely related field preferred. Must have a minimum of three years of training related to cryo-electron microscopy image processing, with emphasis on single particle analysis and a proven track record reflecting mastery in high resolution reconstruction. Competency with supporting computing hardware and high-level competency with relevant data image processing software, (e.g., 3DNA, SPIDER, Xmipp, EMAN2, SPARX, FREALIGN, and RELION), experience working in heterogeneous computing environments, including recent experience with Linux, Apple, and Windows operating systems, and familiarity with HPC job scheduling tools (e.g. SLURM) necessary. Ability and willingness to develop competency in relevant sample preparation and CryoEM operations, and to work in and support multidisciplinary research necessary. Must possess excellent communication, organizational and interpersonal skills. Experience with tomography a plus.